Frontline Plus or Advantage – Which One to Choose for Your Canine?

One of the most crucial parts of keeping your canine companion hale and hearty is to protect them from parasites. Parasitic infestations of fleas and ticks should be treated promptly with appropriate treatments before they cause any harmful diseases. But the question is, which treatment should you use out of the plethora of options available in the market? To make it easier for you, we have come up with two popular and vet-recommended products, Frontline Plus and Advantage.
In this blog post, we will look at the fundamentals of these products and will compare their characteristics with a comparison chart so that you can make an informed choice for your furry companion. Let’s begin!
Frontline Plus vs. Advantage – An overview
Frontline Plus is a potent, fast-acting, long-lasting, spot-on flea and tick treatment for dogs and puppies 8 weeks of age and older, weighing at least 5 lbs. This topical treatment kills fleas, ticks and their life stages. This monthly formula is also beneficial in eliminating chewing lice infestations and controlling sarcoptic mange infestations. Moreover, it kills fleas that may cause flea allergy dermatitis (FAD) and aids in the prevention of Lyme disease and other tick-borne diseases.
Key Specifications
- Highly effective, monthly flea and tick treatment
- Rapid-action, waterproof solution
- Long-lasting formula offers hassle-free application
- Kills adult fleas, flea eggs and flea larvae
- Prevents existing and future flea infestations
- Stops all flea life stages (eggs, larvae and pupae) from developing
- Reduces the incidence of flea allergy dermatitis (FAD)
- Kills all tick life stages (larva, nymph and adult)
- Effective against American dog tick, Brown dog tick, Lone star tick and Deer tick
- Prevents Lyme disease and other tick-borne diseases
- Controls sarcoptic mange and eliminates chewing lice infestations
- Suitable for dogs and puppies 8 weeks of age and older, weighing at least 5 lbs
- Safe for use in breeding, pregnant and lactating dogs
Advantage is a highly effective, quick-action, monthly spot-on treatment for dogs and puppies. This easy-to-administer formula effectively kills fleas and flea larvae, treats and prevents flea infestations and controls lice infestations. It also aids in reducing the incidence of flea allergy dermatitis (FAD).
Key Specifications
- Topical monthly flea treatment
- Rapid-action formula offers easy administration
- Kills adult fleas and flea larvae
- Helps in controlling lice infestations
- Prevents re-infestation by breaking the flea life cycle
- Eliminates fleas that may cause flea allergy dermatitis (FAD)
- Stops fleas from feeding within 3-5 minutes
- Suitable for puppies from birth
- Safe for use in pregnant and lactating dogs
Differences between Frontline Plus and Advantage
Mentioned below are the key differences between Frontline Plus and Advantage:
- Composition: Frontline Plus contains Fipronil and (S)-Methoprene as active ingredients, whereas Advantage is formulated with Imidacloprid.
- Tick coverage: Frontline Plus kills all tick life stages (larva, nymph and adult), including American dog tick, Brown dog tick, Lone star tick and Deer tick, whereas Advantage does not offer protection against ticks.
- Other parasites: Frontline Plus offers protection against fleas, ticks, sarcoptic mange and chewing lice. On the other hand, Advantage protects against fleas and lice infestations.
- Lyme disease: Frontline Plus helps prevent Lyme disease by killing deer ticks, whereas Advantage has no role in protection against Lyme disease.
- Suitability: Frontline Plus is suitable dogs and puppies 8 weeks of age and older, weighing at least 5 lbs. On the other hand, Advantage is recommended for puppies from birth.
Similarities between Frontline Plus and Advantage
Here are the basic similarities between Frontline Plus and Advantage:
- Flea coverage: Frontline Plus and Advantage effectively kill adult fleas, flea larvae, break the flea life cycle and prevents future infestations. Moreover, they are beneficial in reducing the incidence of flea allergy dermatitis (FAD).
- Mode of application: Both Frontline Plus and Advantage are easy-to-use spot-on treatments that should be applied topically every month.
- Safety: Both the treatments are safe for use in pregnant and lactating dogs.
Frontline Plus and Advantage – Comparison Table
The chart below shows the comparison of the characteristics of Frontline Plus and Advantage:

Which one is better – Frontline Plus or Advantage?
In the end, we can clearly see that both Frontline Plus and Advantage are effective monthly flea treatments for dogs that offer hassle-free administration. However, they both carry certain differences in terms of their ingredients, parasite coverage and suitability. Educate yourself with the information mentioned in this blog and choose the one that suits your pet’s preferences and protection requirements. No matter what you choose, don’t forget to consult your vet for tailored recommendations.

David joined CanadaVetCare in 2013 as a product analyst and veterinary assistant. Being a passionate pet lover and keen animal health researcher, David had always found ways and solutions to help pet parents to improve their pets’ health. He is always happy to answer pet health-related queries and recommending pet parents for the right pet product for their furry companions.